Description

2-(2-[4-(3-Benzyloxy-Phenylsulfanyl)-2-Chloro-Phenyl]-Ethyl)-2-Fluoro-Malonic Acid Diethyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a versatile building block for creating novel therapeutic agents. It is primarily utilized by pharmaceutical manufacturers and R&D laboratories focused on developing new drugs, particularly in areas requiring sophisticated fluorinated and sulfur-containing molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in drug discovery programs for the development of new chemical entities, especially those targeting specific receptors or enzymes.
• Fluorinated Compound Synthesis: Serves as a precursor for introducing fluorine atoms into target molecules, a common strategy to enhance metabolic stability and bioavailability.
• Sulfur-Containing Molecule Fabrication: Utilized in constructing molecules with phenylsulfanyl (thioether) linkages, which are important in various pharmacologically active compounds.
• Process Development & Scale-Up: Employed in optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	2-(2-[4-(3-Benzyloxy-Phenylsulfanyl)-2-Chloro-Phenyl]-Ethyl)-2-Fluoro-Malonic Acid Diethyl Ester
CAS No.	1023648-24-9
Molecular Formula	C28H28ClFO4S
Molecular Weight	515.04 g/mol
Synonyms	Diethyl 2-(2-{4-[(3-benzyloxy)phenyl]sulfanyl}-2-chlorophenyl)ethyl-2-fluoromalonate; 2-Fluoro-2-{2-[4-(3-benzyloxyphenylsulfanyl)-2-chlorophenyl]ethyl}malonic Acid Diethyl Ester; 2-Fluoro-2-[2-(4-{[3-(benzyloxy)phenyl]sulfanyl}-2-chlorophenyl)ethyl]propanedioic Acid Diethyl Ester; 1023648-24-9; Fluoromalonate Derivative CAS 1023648-24-9; Benzyloxyphenylsulfanyl Chlorophenyl Ethyl Fluoromalonate Ester
EINECS	Contact for details

Quality Control

Every batch of 2-(2-[4-(3-Benzyloxy-Phenylsulfanyl)-2-Chloro-Phenyl]-Ethyl)-2-Fluoro-Malonic Acid Diethyl Ester is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request, providing full traceability and supporting your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive (hygroscopic); ensure containers are sealed tightly after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.