Description

Dicyclohexyl(2,2-Diphenyl-1-Methylcyclopropyl)Phosphine (Cy-Cbridp) is a specialized, sterically demanding monodentate phosphine ligand designed for advanced catalytic applications. Its unique structure, featuring a bulky, rigid cyclopropyl backbone, provides exceptional control over metal coordination and reaction selectivity, making it a critical component for high-performance catalysts. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical outcomes in cross-coupling, hydrogenation, and hydrofunctionalization reactions.

Application

• Homogeneous Catalysis: As a key ligand in palladium- and nickel-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination) for C-C and C-N bond formation.
• Asymmetric Synthesis: Enabling enantioselective transformations in the synthesis of chiral active pharmaceutical ingredients (APIs) and agrochemical intermediates.
• Olefin Polymerization: Serving as a ligand component in late-transition metal catalysts for the production of specialty polyolefins with controlled architectures.
• Hydrogenation Catalysts: Modifying rhodium or ruthenium complexes for the selective reduction of challenging unsaturated substrates.
• Academic & Industrial R&D: A valuable tool for developing novel catalytic methodologies and optimizing existing synthetic routes.
• Material Science: Potential use in the synthesis of metal-organic frameworks (MOFs) or surface-modified nanoparticles for catalytic applications.

Basic Information

Item	Detail
Product Name	Dicyclohexyl(2,2-Diphenyl-1-Methylcyclopropyl)Phosphine (Cy-Cbridp)
CAS No.	1023330-38-2
Molecular Formula	C28H37P
Molecular Weight	404.57 g/mol
Synonyms	Cy-Cbridp; Dicyclohexyl(2,2-diphenyl-1-methylcyclopropyl)phosphine; (2,2-Diphenyl-1-methylcyclopropyl)dicyclohexylphosphine; cBRIDP; cBRIDP ligand; t-Bu-cBRIDP analog; Bulky cyclopropyl phosphine ligand
EINECS	Contact for details

Quality Control

Every batch of Cy-Cbridp is manufactured and tested under strict quality management systems to ensure consistency and reliability for sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by NMR and HPLC), identity confirmation, and moisture content. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.