Description

n-[(1R,2R)-2-Aminocyclohexyl]-1,1,1-Trifluoro-Methanesulfonamide CAS NO 1023284-00-5 is a high-purity, chiral trifluoromethanesulfonamide derivative, a key building block in advanced organic synthesis. Its value lies in its unique stereochemistry and the triflyl group, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethanesulfonamide moiety can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Peptidomimetics and PROTACs: Incorporated into the design of peptidomimetics and Proteolysis-Targeting Chimeras (PROTACs) due to its ability to influence molecular recognition and degradation profiles.
• Material Science Research: Explored as a monomer or modifier in the synthesis of specialty polymers with unique surface properties or fluorinated characteristics.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	n-[(1R,2R)-2-Aminocyclohexyl]-1,1,1-Trifluoro-Methanesulfonamide
CAS No.	1023284-00-5
Molecular Formula	C7H13F3N2O2S
Molecular Weight	246.25 g/mol
Synonyms	(1R,2R)-N-(2-Aminocyclohexyl)-1,1,1-trifluoromethanesulfonamide; (1R,2R)-2-Amino-N-(trifluoromethylsulfonyl)cyclohexanamine; 1,1,1-Trifluoro-N-[(1R,2R)-2-aminocyclohexyl]methanesulfonamide; (1R,2R)-2-Triflylamidocyclohexylamine; (1R,2R)-2-Amino-N-(triflyl)cyclohexylamine; (1R,2R)-2-Trifluoromethanesulfonamidocyclohexanamine; Chiral Triflyl Cyclohexylamine Derivative
EINECS	Contact for details

Quality Control

Our n-[(1R,2R)-2-Aminocyclohexyl]-1,1,1-Trifluoro-Methanesulfonamide is manufactured under cGMP-compliant conditions to ensure the highest standards of purity and consistency required for pharmaceutical research. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess verification. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.