Description

2-Chloro-5-(Trifluoromethoxy)Phenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its unique halogenated and trifluoromethoxy-substituted aromatic structure, which enables precise cross-coupling reactions to create complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for Suzuki-Miyaura coupling and other palladium-catalyzed transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, leveraging the stability and bioactivity imparted by the trifluoromethoxy and chloro substituents.
• Material Science Research: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a versatile boronic acid partner in Pd-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes and diagnostic agents due to its ability to form stable covalent bonds under mild conditions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for drug discovery.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1022922-16-2
Molecular Formula	C7H5BClF3O3
Molecular Weight	239.38 g/mol
Synonyms	[2-Chloro-5-(trifluoromethoxy)phenyl]boronic acid; (2-Chloro-5-(trifluoromethoxy)phenyl)boronic acid; 2-Chloro-5-trifluoromethoxybenzeneboronic acid; 2-Chloro-α,α,α-trifluoro-p-anisylboronic acid; Boronic acid, B-[2-chloro-5-(trifluoromethoxy)phenyl]-; 2-Chloro-5-(trifluoromethoxy)benzeneboronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF Titration)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.