Description

N,o-Didesmethyl-(Rac-Venlafaxine) Glucuronide Hydrochloride is a high-purity reference standard and key metabolite of the antidepressant venlafaxine. This compound is essential for pharmaceutical research and development, particularly in the fields of bioanalytical method development and pharmacokinetic studies. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug metabolism and safety testing.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative and qualitative analysis of venlafaxine and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for studying the metabolic pathways, clearance, and exposure levels of venlafaxine in preclinical and clinical research.
• Bioanalytical Method Development: Serves as a key analyte for developing and validating sensitive HPLC-MS/MS or LC-UV methods for therapeutic drug monitoring.
• Impurity Profiling: Employed in the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.
• Toxicology Studies: Used to investigate the safety profile and potential toxicological effects of venlafaxine metabolites.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., with the FDA, EMA) to demonstrate understanding of a drug's metabolic fate.

Basic Information

Product Name	N,o-Didesmethyl-(Rac-Venlafaxine) Glucuronide Hydrochloride
CAS No.	1021933-99-2
Molecular Formula	C23H30ClNO9
Molecular Weight	500.94 g/mol
Synonyms	O-Desmethylvenlafaxine Glucuronide; N,O-Didesmethylvenlafaxine Glucuronide HCl; rac-N-Desmethyl-O-desmethylvenlafaxine β-D-Glucuronide Hydrochloride; Venlafaxine Metabolite Glucuronide; 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Glucuronide Hydrochloride
EINECS	Contact for details

Quality Control

Our N,o-Didesmethyl-(Rac-Venlafaxine) Glucuronide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, NMR and MS confirmation of structure, and determination of residual solvents and water content. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to ensure full traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.