Description

o-Desmethyl-(Rac-Venlafaxine) Glucuronide is a key glucuronide metabolite of the antidepressant venlafaxine, serving as a critical reference standard and analytical tool in pharmaceutical research and development. This compound is essential for conducting precise pharmacokinetic and metabolic studies, ensuring accurate quantification and characterization of drug metabolism pathways. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories focused on bioanalysis, drug safety, and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative analysis of venlafaxine and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic fate, clearance, and exposure levels of venlafaxine in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a critical component in developing and validating robust HPLC, LC-MS, or LC-MS/MS assays for therapeutic drug monitoring.
• Impurity Profiling and Characterization: Employed to identify and quantify glucuronidated metabolites as potential impurities in active pharmaceutical ingredient (API) batches.
• Toxicology and Safety Assessment: Used in studies to understand the safety profile and potential toxicity associated with venlafaxine metabolite formation.
• Regulatory Submission Support: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring detailed metabolite identification and quantification.

Basic Information

Product Name	o-Desmethyl-(Rac-Venlafaxine) Glucuronide
CAS No.	1021933-98-1
Molecular Formula	C23H30NO8
Molecular Weight	448.49 g/mol
Synonyms	O-Desmethylvenlafaxine Glucuronide; ODV Glucuronide; (Rac)-O-Desmethylvenlafaxine β-D-Glucuronide; N-Desmethylvenlafaxine Glucuronide (isomeric); Venlafaxine Metabolite Glucuronide; 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Glucuronide; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenyl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our o-Desmethyl-(Rac-Venlafaxine) Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for analytical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and our quality system supports the requirements for reference standard qualification.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.