Description

3-Chloro-5-(Hydroxymethyl)Benzonitrile is a versatile benzonitrile derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a chloro and a hydroxymethyl substituent, makes it a valuable intermediate for constructing complex molecules with high precision. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the chloro and hydroxymethyl groups for structural diversification.
• Liquid Crystal & OLED Material Research: Serves as a starting material for creating advanced organic electronic materials and liquid crystal compounds.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for specialty polymers and high-performance resins.
• Chemical Biology & Proteomics: Utilized as a scaffold or linker in the development of chemical probes and bioconjugation reagents.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Chloro-5-(Hydroxymethyl)Benzonitrile
CAS No.	1021871-35-1
Molecular Formula	C8H6ClNO
Molecular Weight	167.59 g/mol
Synonyms	3-Chloro-5-(hydroxymethyl)benzonitrile; 5-(Hydroxymethyl)-3-chlorobenzonitrile; 3-Chloro-5-(hydroxymethyl)phenyl cyanide; (3-Chloro-5-cyanophenyl)methanol; Benzonitrile, 3-chloro-5-(hydroxymethyl)-; 1021871-35-1
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Hydroxymethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.