Description

Methyl 2-[(2,2,2-Trifluoroethyl)Amino]Acetate CAS NO 1021235-22-2 is a specialized fluorinated amino acid ester, a high-value building block in advanced organic synthesis. Its structure, featuring a trifluoroethylamino moiety, is critical for modulating the physicochemical properties of target molecules, enhancing metabolic stability and lipophilicity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical sectors seeking to incorporate fluorine into novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoroethyl group can improve biological activity and environmental profile.
• Peptidomimetics & Bioactive Molecules: Serves as a fluorinated amino acid analog for constructing peptides and small molecules with enhanced binding affinity and proteolytic resistance.
• Ligand & Catalyst Development: Employed in the synthesis of novel chelating ligands and organocatalysts for asymmetric synthesis and metal complexation.
• Material Science Precursor: Acts as a monomer or functionalization agent for creating specialty polymers and coatings with unique surface properties.
• Chemical Biology Probes: Utilized in the design of fluorinated probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	Methyl 2-[(2,2,2-Trifluoroethyl)Amino]Acetate
CAS No.	1021235-22-2
Molecular Formula	C5H8F3NO2
Molecular Weight	171.12 g/mol
Synonyms	Methyl N-(2,2,2-trifluoroethyl)glycinate; Glycine, N-(2,2,2-trifluoroethyl)-, methyl ester; Methyl (2,2,2-trifluoroethylamino)acetate; 2-[(2,2,2-Trifluoroethyl)amino]acetic acid methyl ester; Methyl 2-(trifluoroethylamino)acetate; N-(Trifluoroethyl)glycine methyl ester; Methyl α-[(2,2,2-trifluoroethyl)amino]acetate
EINECS	Contact for details

Quality Control

Our Methyl 2-[(2,2,2-Trifluoroethyl)Amino]Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.