Description

Zonisamide-D4 is a deuterated internal standard of the anticonvulsant drug Zonisamide, specifically designed for analytical applications. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily used by pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control departments for method development, validation, and bioanalytical studies.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise quantification of Zonisamide in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Used in assay development to monitor Zonisamide concentrations in patient samples, aiding in personalized dosing regimens.
• Drug Metabolism and Disposition Studies: Facilitates the identification and quantification of metabolites in complex biological systems.
• Method Development and Validation: Provides a stable, non-interfering reference point for developing robust, sensitive, and selective analytical methods compliant with ICH and FDA guidelines.
• Quality Control and Impurity Profiling: Assists in the analysis of pharmaceutical formulations and raw materials to ensure product purity and consistency.

Basic Information

Product Name	Zonisamide-D4
CAS No.	1020720-04-0
Molecular Formula	C8D4H4N2O3S
Molecular Weight	216.25 g/mol
Synonyms	1,2-Benzisoxazole-3-methanesulfonamide, 4,5,6,7-tetradeutero-; Zonisamide (tetradeutero); Zonisamide-d4; 1,2-Benzisoxazole-3-methanesulfonamide-d4; 3-(Sulfamoylmethyl)-1,2-benzisoxazole-d4; 4,5,6,7-Tetradeuterozonisamide; ZNS-d4; Isotopically Labeled Zonisamide
EINECS	Contact for details

Quality Control

Our Zonisamide-D4 is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch undergoes comprehensive testing, including HPLC purity, NMR, and mass spectrometry to confirm chemical and isotopic identity. Certificates of Analysis (COA) detailing batch-specific results for chemical purity, isotopic purity (D-enrichment), and residual solvents are provided and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.