Description

D,L-Venlafaxine-D6 CAS NO 1020720-02-8 is a high-purity, deuterium-labeled internal standard critical for ensuring analytical accuracy and reliability in quantitative bioanalysis. This stable isotope-labeled compound is essential for precise quantification of venlafaxine and its metabolites in complex biological matrices using advanced techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology labs for method development, validation, and routine drug monitoring studies.

Application

• Internal Standard for LC-MS/MS Bioanalysis: Used as a quantitative reference for venlafaxine and its major metabolite, O-desmethylvenlafaxine, in pharmacokinetic (PK) and toxicokinetic (TK) studies.
• Pharmaceutical Research & Development: Critical for method development and validation in drug discovery and clinical trial sample analysis.
• Forensic and Clinical Toxicology: Enables accurate measurement of venlafaxine concentrations in human plasma, serum, or urine for therapeutic drug monitoring (TDM) and overdose investigations.
• Metabolite Identification and Profiling: Aids in the identification and quantification of drug metabolites in metabolism and disposition (ADME) studies.
• Quality Control in Reference Material Production: Serves as a key component in the preparation of certified reference materials (CRMs) and quality control samples.

Basic Information

Product Name	D,L-Venlafaxine-D6
CAS No.	1020720-02-8
Molecular Formula	C17H21D6NO2
Molecular Weight	279.41 g/mol (approx.)
Synonyms	Venlafaxine-d6; (±)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol-d6; DL-Venlafaxine-d6; (R/S)-Venlafaxine-d6; 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol (hexadeuterated); Venlafaxine (phenyl-d6) Hydrochloride (related salt form); Effexor-d6 (labeled analog of trade name).
EINECS	Contact for details

Quality Control

Our D,L-Venlafaxine-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment (by MS), and residual solvents. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific pharmacopeial or client specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.