Description

Sulfamethoxazole D4 (Benzene D4) CAS NO 1020719-86-1 is a deuterated analog of the widely used antibiotic sulfamethoxazole, where four hydrogen atoms on the benzene ring are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism, pharmacokinetic studies, and residue analysis.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of sulfamethoxazole and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• Veterinary Drug Residue Analysis: Ensures accurate monitoring of sulfamethoxazole residues in food-producing animals to comply with food safety regulations (e.g., EU MRLs).
• Environmental Fate Studies: Aids in tracing the environmental breakdown and persistence of sulfonamide antibiotics in water and soil samples.
• Pharmaceutical Quality Control: Supports method development and validation for the assay and impurity profiling of sulfamethoxazole in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Clinical Research: Facilitates reliable therapeutic drug monitoring (TDM) in patients to optimize dosing regimens and ensure efficacy.

Basic Information

Product Name	Sulfamethoxazole D4 (Benzene D4)
CAS No.	1020719-86-1
Molecular Formula	C10H7D4N3O3S
Molecular Weight	257.31 g/mol (approx.)
Synonyms	4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide-d4 (benzene ring); Sulfamethoxazole-d4 (benzene-d4); SMZ-d4; Deuterated Sulfamethoxazole; [²H₄]-Sulfamethoxazole; 3-(p-Aminophenylsulfonamido)-5-methylisoxazole-d4; N1-(5-Methyl-3-isoxazolyl)sulfanilamide-d4
EINECS	Contact for details

Quality Control

Our Sulfamethoxazole D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment (typically >98 atom % D), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95% (by NMR)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.