Description

Sulfamerazin-D4 CAS NO 1020719-84-9 is a deuterated analog of the sulfonamide antibiotic Sulfamerazine, where four hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reproducibility in analytical methods. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical chemistry departments for drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and quality control.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in the quantitative bioanalysis of Sulfamerazine and related sulfonamides in biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in tracing and quantifying the parent drug and its metabolites during preclinical and clinical pharmacokinetic research.
• Method Development and Validation: Enables the development of highly specific and sensitive analytical methods compliant with FDA and ICH guidelines.
• Quality Control & Assurance: Supports impurity profiling and assay verification in pharmaceutical manufacturing processes.
• Stable Isotope Dilution Analysis (SIDA): Applied in precise quantification techniques to correct for analyte loss during sample preparation.
• Research Chemical: Utilized in academic and industrial research investigating sulfonamide mechanisms, environmental fate, or residue analysis.

Basic Information

Product Name	Sulfamerazin-D4
CAS No.	1020719-84-9
Molecular Formula	C11H8D4N4O2S
Molecular Weight	268.33 g/mol (approx.)
Synonyms	4-Amino-N-(4-methyl-2-pyrimidinyl-D4)benzenesulfonamide; Sulfamerazine-d4; N1-(4-Methyl-2-pyrimidinyl-D4)sulfanilamide; Sulfamerazine (methyl-D4); Deuterated Sulfamerazine; [2H4]-Sulfamerazine; Stable Isotope Labeled Sulfamerazine
EINECS	Contact for details

Quality Control

Our Sulfamerazin-D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and Mass Spectrometry, to confirm identity, isotopic enrichment (typically ≥98 atom % D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.