Description

Oxcarbazepine-D4 (Major) is a high-purity, stable isotope-labeled analog of the anticonvulsant drug oxcarbazepine, specifically deuterated at four key positions. This compound is an essential internal standard for the precise and accurate quantification of oxcarbazepine and its metabolites in biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic manufacturers engaged in bioanalytical method development, pharmacokinetic studies, and therapeutic drug monitoring.

Application

• Bioanalytical Method Development: Serves as a critical internal standard for developing and validating sensitive and specific LC-MS/MS methods for oxcarbazepine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration in plasma, serum, and other biological fluids to study absorption, distribution, metabolism, and excretion.
• Therapeutic Drug Monitoring (TDM): Used in clinical assays to monitor oxcarbazepine levels in patient samples, ensuring efficacy and minimizing toxicity.
• Metabolite Identification and Profiling: Aids in the identification and quantification of oxcarbazepine metabolites in complex biological systems.
• Doping Control and Forensic Analysis: Employed in confirmatory testing protocols for the detection of oxcarbazepine in sports and forensic toxicology.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assays for oxcarbazepine drug substance and product.

Basic Information

Product Name	Oxcarbazepine-D4 (Major)
CAS No.	1020719-71-4
Molecular Formula	C15H8D4N2O2
Molecular Weight	256.29 g/mol
Synonyms	10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide-d4 (10,11-dihydro-10-oxo-); 10-Oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide-d4; GP 47680-d4; Trileptal-d4 (labeled); Deuterated Oxcarbazepine (Major); Oxcarb-D4; 5-Carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepine-10-one-d4
EINECS	Contact for details

Quality Control

Every batch of Oxcarbazepine-D4 (Major) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity, chemical purity, and stability. Our quality protocols are designed to meet the stringent requirements of analytical reference standard applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. After opening, handle under an inert atmosphere if possible and reseal immediately.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (D4)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.