Description

(R,S)-n-Nitrosoanabasine-D4 is a deuterated isotopologue of the nitrosamine n-nitrosoanabasine, a compound of significant interest in analytical and research chemistry. This stable isotope-labeled standard is essential for achieving high accuracy and precision in quantitative mass spectrometry, enabling reliable detection and measurement of trace-level nitrosamines. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical manufacturers engaged in method development, impurity profiling, and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of nitrosamine impurities.
• Pharmaceutical Impurity Testing: Used in the development and validation of analytical methods to detect and quantify genotoxic nitrosamine impurities (e.g., N-nitrosoanabasine) in active pharmaceutical ingredients (APIs) and finished drug products.
• Food and Environmental Safety Analysis: Supports research and monitoring programs for nitrosamine contamination in foodstuffs, tobacco, and environmental samples.
• Metabolic and Pharmacokinetic Studies: Acts as a tracer in advanced research investigating the absorption, distribution, metabolism, and excretion (ADME) of nitrosamine compounds.
• Regulatory Compliance and Method Validation: Essential for laboratories adhering to guidelines from regulatory bodies like the FDA and EMA, ensuring data integrity for regulatory submissions.
• Certified Reference Material (CRM) Production: Used as a primary component in the preparation of certified reference materials for quality control and proficiency testing.

Basic Information

Product Name	(R,S)-n-Nitrosoanabasine-D4
CAS No.	1020719-68-9
Molecular Formula	C10H9D4N3O
Molecular Weight	191.24 g/mol
Synonyms	N-Nitrosoanabasine-d4; 3-(1-Methyl-1,2,5,6-tetrahydro-4-pyridinyl)-1-(2,3,4,5-tetradeuteriopyridin-1-yl)-1-oxidanidyl-diazenium; N-Nitrosoanabasine (deuterated); NAB-d4; N-Nitrosoanabasine isotopologue; 1-Nitroso-1-(3,4,5,6-tetradeuterio-2-pyridinyl)-2-(3,6-dihydro-1-methyl-4-pyridinyl)diazene; Deuterated N-Nitrosoanabasine
EINECS	Contact for details

Quality Control

Our (R,S)-n-Nitrosoanabasine-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical purity. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, and isotopic content are provided to ensure traceability and compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.