Description

Famciclovir-D4 CAS NO 1020719-42-9 is a deuterated analog of the antiviral prodrug famciclovir, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on antiviral drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity reference standard in Liquid Chromatography-Tandem Mass Spectrometry for the precise quantification of famciclovir and its active metabolite, penciclovir, in biological matrices.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical trials.
• Metabolite Profiling: Used in research to identify and quantify the metabolic pathways and breakdown products of famciclovir.
• Bioequivalence Testing: Critical for ensuring the analytical validity of studies comparing generic and brand-name antiviral formulations.
• Method Development & Validation: Serves as a key component in developing and validating robust, GLP/GMP-compliant analytical methods for regulatory submissions.
• Doping Control Analysis: Potential use in forensic and sports anti-doping laboratories for the detection of prohibited antiviral substances.

Basic Information

Product Name	Famciclovir-D4
CAS No.	1020719-42-9
Molecular Formula	C14H15D4N5O4
Molecular Weight	325.36 g/mol (approximate)
Synonyms	Famciclovir-d4; 2-[(Acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate-2,2,3,3-d4; 9-(4-Acetoxy-3-acetoxymethylbut-1-yl)-2-aminopurine-d4; BRL 42810-d4; Deuterated Famciclovir; [2H4]-Famciclovir
EINECS	Contact for details

Quality Control

Our Famciclovir-D4 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for the most demanding analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity (by HPLC), and identification (by NMR and MS). We support compliance with GMP/GLP guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.