Description

Desloratadine D5 is a deuterium-labeled internal standard of the non-sedating antihistamine desloratadine, specifically designed for analytical applications. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analysis in complex biological matrices. It is a critical reagent for pharmaceutical research, bioanalytical method development, and clinical laboratories conducting pharmacokinetic and metabolism studies.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a stable, isotopically labeled reference compound for the precise quantification of desloratadine in bioanalytical assays.
• Pharmacokinetic and Bioavailability Studies: Enables accurate measurement of drug concentration in plasma, serum, and other biological fluids over time.
• Drug Metabolism and Disposition Research (DMPK): Used in mass spectrometry to study the metabolic pathways and clearance of desloratadine.
• Clinical Trial Support: Critical for ensuring data integrity in clinical studies evaluating the efficacy and safety of desloratadine formulations.
• Method Development and Validation: Serves as a key component in developing and validating robust, regulatory-compliant analytical methods (e.g., following FDA, EMA guidelines).
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assays for desloratadine active pharmaceutical ingredient (API) and finished products.

Basic Information

Product Name	Desloratadine D5
CAS No.	1020719-34-9
Molecular Formula	C19H14D5ClN2
Molecular Weight	313.85 g/mol
Synonyms	Desloratadine-d5; 8-Chloro-6,11-dihydro-11-(4-piperdinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-d5; 8-Chloro-11-(4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-d5; Descarboethoxyloratadine-d5; Sch 34117-d5; Neoclarityn-d5; Aerius-d5; Clarinex-d5
EINECS	Contact for details

Quality Control

Our Desloratadine D5 is manufactured under strict quality systems to ensure it meets the exacting requirements for use as an analytical standard. Each batch undergoes rigorous testing, including HPLC for chemical purity and MS for isotopic enrichment verification. A comprehensive Certificate of Analysis (COA) detailing identity, purity, isotopic purity, and chromatographic data is provided with every shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.