Description

4-Acetaminophen-D3 Sulfate is a stable isotope-labeled internal standard of the major metabolite of acetaminophen. This compound is essential for ensuring the accuracy and precision of quantitative bioanalytical methods, particularly in pharmacokinetic and toxicological studies. It is a critical reagent for researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and clinical diagnostics sectors who require reliable standards for mass spectrometry-based assays.

Application

• LC-MS/MS Internal Standard: Primary use as a deuterated internal standard for the precise quantification of acetaminophen sulfate metabolite in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to understand the metabolic fate, clearance rates, and bioavailability of acetaminophen.
• Toxicology and Forensic Analysis: Enables accurate measurement of acetaminophen and its metabolites in cases of overdose or adverse drug reaction investigations.
• Clinical Research: Supports biomarker analysis in clinical trials studying pain management, fever reduction, and drug safety profiles.
• Method Development and Validation: Serves as a key component in developing, optimizing, and validating robust bioanalytical methods according to FDA, EMA, or ICH guidelines.
• Quality Control in Reference Material Production: Used in the preparation and certification of certified reference materials (CRMs) for clinical chemistry.

Basic Information

Product Name	4-Acetaminophen-D3 Sulfate
CAS No.	1020718-78-8
Molecular Formula	C8H5D3NO5S
Molecular Weight	232.24 g/mol
Synonyms	Acetaminophen-d3 Sulfate; Paracetamol-d3 Sulfate; APAP-d3 Sulfate; N-Acetyl-p-aminophenol-d3 Sulfate; 4'-Hydroxyacetanilide-d3 Sulfate; 4-Acetamidophenol-d3 Sulfate; Deuterated Acetaminophen Sulfate; [2H3]-Acetaminophen Sulfate
EINECS	Contact for details

Quality Control

Our 4-Acetaminophen-D3 Sulfate is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, isotopic enrichment, and analytical results. We support compliance with ISO 17034 for reference material producers.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.