Description

1-(4-Fluoro-Phenyl)-5-Trifluoromethyl-Pyrrolidin-2-One is a high-value, fluorinated pyrrolidinone derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a fluoro-phenyl and a trifluoromethyl group, makes it an essential intermediate for developing novel pharmaceuticals and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating new active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and metabolic disease therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve biological activity and environmental stability.
• Material Science Research: Employed as a monomer or precursor for developing specialty polymers and liquid crystals with specific optical or electronic properties.
• Chemical Biology Probes: Serves as a scaffold for designing molecular probes and inhibitors used in biochemical and pharmacological research.
• Process Chemistry: Utilized in route scouting and scale-up processes for the commercial manufacturing of fluorinated fine chemicals.

Basic Information

Product Name	1-(4-Fluoro-Phenyl)-5-Trifluoromethyl-Pyrrolidin-2-One
CAS No.	1020717-94-5
Molecular Formula	C11H9F4NO
Molecular Weight	247.19 g/mol
Synonyms	1-(4-Fluorophenyl)-5-(trifluoromethyl)pyrrolidin-2-one; 5-(Trifluoromethyl)-1-(4-fluorophenyl)-2-pyrrolidinone; 1-(p-Fluorophenyl)-5-trifluoromethyl-2-pyrrolidinone; 1020717-94-5; 4-Fluoro-N-(3,3,3-trifluoro-2-oxopropyl)aniline (linear formula equivalent); FPPO (abbreviation); Fluorinated Pyrrolidinone Intermediate
EINECS	Contact for details

Quality Control

Our 1-(4-Fluoro-Phenyl)-5-Trifluoromethyl-Pyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.