Description

4'-Phosphopantetheine is a crucial biochemical cofactor and the active prosthetic group of acyl carrier proteins (ACP) and peptidyl carrier proteins (PCP). This compound matters significantly in the biosynthesis of fatty acids, polyketides, and non-ribosomal peptides, serving as a central molecular handle for substrate shuttling and chain elongation. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and synthetic biology sectors who are developing novel antibiotics, anticancer agents, or engineered biosynthetic pathways.

Application

• Enzymology Research: Critical for studying and reconstituting the activity of fatty acid synthases (FAS), polyketide synthases (PKS), and non-ribosomal peptide synthetases (NRPS).
• Pharmaceutical Development: Used in the research and production of complex natural product-derived drugs, including antibiotics and antifungals.
• Biocatalyst Engineering: Serves as a cofactor or building block for engineering synthetic enzyme complexes and cell-free production systems.
• Biochemical Assays: Employed in high-throughput screening (HTS) assays to identify inhibitors or activators of carrier protein-dependent synthesis.
• Metabolic Pathway Analysis: A key tool for investigating cellular metabolism related to lipid and secondary metabolite biosynthesis.
• Diagnostic Reagent Manufacturing: Potential use in formulating specialized diagnostic kits for metabolic disorders.

Basic Information

Product Name	4'-Phosphopantetheine
CAS No.	1019842-99-9
Molecular Formula	C11H23N3O7P
Molecular Weight	340.29 g/mol
Synonyms	Phosphopantetheine; D-4'-Phosphopantetheine; (R)-4'-Phosphopantetheine; Coenzyme A precursor; Pantetheine 4'-phosphate; ACP prosthetic group; P-pant; PPant; 4'-O-Phosphonato-D-pantetheine
EINECS	Contact for details

Quality Control

Our 4'-Phosphopantetheine is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity research and process standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.