Description

Chlorpromazine-D6 Oxalate (N,n-Dimethyl-D6) is a deuterium-labeled analog of the classic antipsychotic drug chlorpromazine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is critical for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities focused on neuropharmacology and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in liquid chromatography-tandem mass spectrometry for the analysis of chlorpromazine and its metabolites in biological matrices.
• Pharmacokinetic Studies: Enables precise measurement of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Profiling: Used in the identification and quantification of chlorpromazine metabolites to understand its metabolic pathways.
• Bioanalytical Method Development & Validation: Critical for developing, validating, and ensuring the robustness of analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Forensic & Clinical Toxicology: Supports accurate quantification in forensic analysis and therapeutic drug monitoring (TDM) programs.
• Drug Impurity Testing: Can be utilized as a reference in stability studies and impurity profiling of pharmaceutical formulations.

Basic Information

Product Name	Chlorpromazine-D6 Oxalate (N,n-Dimethyl-D6)
CAS No.	1019646-35-5
Molecular Formula	C17H13D6ClN2S • C2H2O4
Molecular Weight	Contact for details
Synonyms	2-Chloro-10-[3-(dimethylamino-d6)propyl]phenothiazine Oxalate; 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl(trideuteriomethyl)propan-1-amine Oxalate; Chlorpromazine-d6 (dimethyl-d6) Oxalate; Deuterated Chlorpromazine Oxalate; CPZ-d6 Oxalate
EINECS	Contact for details

Quality Control

Every batch of Chlorpromazine-D6 Oxalate is manufactured and tested under strict quality systems to ensure the highest standards of isotopic purity and chemical identity required for analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic techniques.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity (D-content)	≥99.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.