Description

2-Chloro-n-(3-Fluorophenyl)Pyridine-4-Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its distinct halogenated pyridine-carboxamide structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need this material to develop next-generation drug candidates, leveraging its precise chemical functionality for structure-activity relationship (SAR) studies and process optimization.

Application

This specialized intermediate is designed for advanced synthetic applications, primarily serving the pharmaceutical and agrochemical research sectors.

• Pharmaceutical Intermediate: A crucial building block for the research and development of new drug candidates, especially in kinase inhibitor programs.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where its halogenated structure provides specific bioactivity.
• Chemical Biology Research: Serves as a probe or precursor in the study of protein-ligand interactions and enzyme inhibition mechanisms.
• Material Science: Potential precursor for the synthesis of functionalized ligands used in catalysis or advanced polymers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes.

Basic Information

Product Name	2-Chloro-n-(3-Fluorophenyl)Pyridine-4-Carboxamide
CAS No.	1019323-09-1
Molecular Formula	C12H8ClFN2O
Molecular Weight	250.66 g/mol
Synonyms	2-Chloro-N-(3-fluorophenyl)pyridine-4-carboxamide; 2-Chloro-N-(3-fluorophenyl)-4-pyridinecarboxamide; 4-Pyridinecarboxamide, 2-chloro-N-(3-fluorophenyl)-; N-(3-Fluorophenyl)-2-chloropyridine-4-carboxamide; 2-Chloro-N-(3-fluorophenyl)isonicotinamide; 1019323-09-1; AKOS025311315; Z57127955
EINECS	Contact for details

Quality Control

Our 2-Chloro-n-(3-Fluorophenyl)Pyridine-4-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% to ≥98% by HPLC), residual solvents, and specific impurities is provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for high-purity grades. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.