Description

1-(1-Acetylpiperidine-4-Yl)-2-Chloroethanone is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine-acetyl and chloroacetyl functional groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, especially in neurological and psychiatric disorder research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to create new chemical entities.
• Custom Synthesis: Serves as a versatile starting material for contract research organizations (CROs) and CDMOs for bespoke chemical synthesis projects.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or affinity labels for biochemical and pharmacological studies due to its reactive chloroacetyl group.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-(1-Acetylpiperidine-4-Yl)-2-Chloroethanone
CAS No.	1018965-84-8
Molecular Formula	C9H14ClNO2
Molecular Weight	203.67 g/mol
Synonyms	4-(2-Chloroacetyl)-1-acetylpiperidine; 1-Acetyl-4-(2-chloroacetyl)piperidine; 2-Chloro-1-[1-(acetyl)piperidin-4-yl]ethanone; 2-Chloro-1-(1-acetylpiperidin-4-yl)ethan-1-one; 1-(1-Acetyl-4-piperidinyl)-2-chloroethanone; 4-(Chloroacetyl)-1-acetylpiperidine; N-Acetyl-4-(2-chloroacetyl)piperidine
EINECS	Contact for details

Quality Control

Our 1-(1-Acetylpiperidine-4-Yl)-2-Chloroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.