Description

(2E)-3-(3-Iodo-5-Methylphenyl)-2-Propenenitrile is a specialized organic building block featuring a conjugated cyanoalkene (acrylonitrile) moiety attached to a halogenated aromatic ring. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in pharmaceutical and advanced material research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as Suzuki-Miyaura cross-coupling reactions and the synthesis of functionalized stilbenes or other fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring halogenated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the iodo and nitrile groups offer unique reactivity.
• Material Science Research: Acts as a monomer or building block for the development of organic semiconductors, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) due to the presence of the reactive iodine atom.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, low-volume specialty chemicals.

Basic Information

Product Name	(2E)-3-(3-Iodo-5-Methylphenyl)-2-Propenenitrile
CAS No.	1018450-07-1
Molecular Formula	C10H8IN
Molecular Weight	269.08 g/mol
Synonyms	(E)-3-(3-Iodo-5-methylphenyl)acrylonitrile; trans-3-(3-Iodo-5-methylphenyl)-2-propenenitrile; 2-Propenenitrile, 3-(3-iodo-5-methylphenyl)-, (2E)-; 3-(3-Iodo-5-methylphenyl)acrylonitrile; (E)-3-(3-Iodo-5-methylphenyl)-2-propenenitrile; (E)-3-(3-Iodo-5-methylphenyl)prop-2-enenitrile
EINECS	Contact for details

Quality Control

Our (2E)-3-(3-Iodo-5-Methylphenyl)-2-Propenenitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory needs in advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, extended exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.