Description

[1-(2,2-Difluoroethyl)-4-(Difluoromethyl)-3-Methyl-6-Oxo-1,6-Dihydro-7H-Pyrazolo[3,4-B]Pyridin-7-Yl]Acetic Acid is a high-purity, fluorinated pyrazolopyridine derivative serving as a critical advanced pharmaceutical intermediate. This compound is essential for the research and development of novel therapeutic agents, particularly in oncology and other disease areas targeting specific enzymatic pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Oncology Research: Used in the development of preclinical and clinical-stage compounds for cancer treatment.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Research: Potential use as a tool compound or probe for studying biological mechanisms in enzymatic assays.
• Custom Synthesis: Starting material for contract manufacturing organizations (CMOs) producing bespoke molecules for client pipelines.
• Process Chemistry Development: Used in scaling up and optimizing synthetic routes for commercial API production.

Basic Information

Product Name	[1-(2,2-Difluoroethyl)-4-(Difluoromethyl)-3-Methyl-6-Oxo-1,6-Dihydro-7H-Pyrazolo[3,4-B]Pyridin-7-Yl]Acetic Acid
CAS No.	1018052-01-1
Molecular Formula	C₁₄H₁₂F₄N₃O₃
Molecular Weight	346.26 g/mol
Synonyms	7H-Pyrazolo[3,4-b]pyridine-7-acetic acid, 1-(2,2-difluoroethyl)-4-(difluoromethyl)-3-methyl-6-oxo-1,6-dihydro-; 1-(2,2-Difluoroethyl)-4-(difluoromethyl)-3-methyl-6-oxo-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-ylacetic acid; Acetic acid, [1-(2,2-difluoroethyl)-4-(difluoromethyl)-3-methyl-6-oxo-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]-; CAS 1018052-01-1
EINECS	Contact for details

Quality Control

Our [1-(2,2-Difluoroethyl)-4-(Difluoromethyl)-3-Methyl-6-Oxo-1,6-Dihydro-7H-Pyrazolo[3,4-B]Pyridin-7-Yl]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities to meet the exacting standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkali and fluorides; ensure it is stored separately from such materials. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.