Description

(R)-6,8-Difluoro-1,2,3,4-Tetrahydronaphthalen-2-Ol is a chiral fluorinated tetralin derivative, a high-value building block in advanced organic synthesis. Its significance lies in its role as a key chiral intermediate for the development of novel pharmaceuticals, particularly in central nervous system (CNS) and cardiovascular research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require enantiomerically pure intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential drug candidates targeting serotonin and dopamine receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic agents with improved efficacy and selectivity.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate in catalytic asymmetric transformations to create complex molecular architectures.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Used as an analytical standard for quality control and method development in chiral HPLC analysis.
• Biochemical Tool Compound: Potential use in pharmacological assays to study receptor-ligand interactions and signaling pathways.

Basic Information

Product Name	(R)-6,8-Difluoro-1,2,3,4-Tetrahydronaphthalen-2-Ol
CAS No.	1017956-76-1
Molecular Formula	C₁₀H₁₀F₂O
Molecular Weight	184.18 g/mol
Synonyms	(2R)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-ol; (R)-6,8-Difluoro-2-tetralol; (R)-6,8-Difluoro-3,4-dihydronaphthalen-2(1H)-one (tautomer); (R)-6,8-Difluoro-α-tetralol; (2R)-6,8-Difluoro-3,4-dihydro-2H-naphthalen-2-ol; (R)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthol; (R)-6,8-Difluoro-2-hydroxy-1,2,3,4-tetrahydronaphthalene
EINECS	Contact for details

Quality Control

Our (R)-6,8-Difluoro-1,2,3,4-Tetrahydronaphthalen-2-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure high chemical and optical purity suitable for research and development applications. Certificates of Analysis (COA) with detailed specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.