Description

1-Cbz-3-Amino-4-Hydroxymethylpyrrolidine is a protected pyrrolidine derivative, a crucial chiral building block in modern organic synthesis. Its value lies in its bifunctional nature, featuring both a protected amine (Cbz) and a hydroxymethyl group, enabling precise and controlled construction of complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other bioactive nitrogen-containing heterocycles.
• Peptidomimetics & Drug Discovery: Serves as a constrained proline analog or scaffold in the design and development of novel peptidomimetic drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides that require specific chiral centers for optimal activity.
• Ligand & Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, complex chiral intermediates.

Basic Information

Product Name	1-Cbz-3-Amino-4-Hydroxymethylpyrrolidine
CAS No.	1017789-40-0
Molecular Formula	C₁₃H₁₈N₂O₃
Molecular Weight	250.29 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-amino-4-(hydroxymethyl)pyrrolidine; 3-Amino-4-(hydroxymethyl)-1-[(phenylmethoxy)carbonyl]pyrrolidine; 1-Cbz-3-amino-4-hydroxymethylpyrrolidine; N-Cbz-3-amino-4-(hydroxymethyl)pyrrolidine; (3-Amino-4-hydroxymethyl-pyrrolidin-1-yl)-phenyl-methanone; Benzyl 3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1-Cbz-3-Amino-4-Hydroxymethylpyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.