Description

4-Bromothiazole-2-Carbonitrile is a versatile brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its dual functionalization, featuring both a reactive bromine atom and a nitrile group, which allows for sequential and diverse derivatization. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting various disease pathways.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the thiazole core's bioactivity.
• Material Science Research: Serves as a monomer or functional unit in the creation of specialized polymers, liquid crystals, or organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed reactions (e.g., Suzuki, Stille) to introduce complex aryl or heteroaryl groups.
• Nitrile Transformation: The cyano group can be hydrolyzed to amides or acids, reduced to amines, or used to form heterocycles like tetrazoles.
• Ligand and Catalyst Development: Employed in the design of novel chelating ligands for metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	4-Bromothiazole-2-Carbonitrile
CAS No.	1017781-52-0
Molecular Formula	C4HBrN2S
Molecular Weight	189.03 g/mol
Synonyms	2-Cyano-4-bromothiazole; 4-Bromo-2-thiazolecarbonitrile; 4-Bromothiazole-2-carbonitrile; 4-Bromo-1,3-thiazole-2-carbonitrile; 2-Thiazolecarbonitrile, 4-bromo-; Thiazole, 4-bromo-2-cyano-; Bromothiazolecarbonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromothiazole-2-Carbonitrile is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.