Description

2-Ethoxy-3,5-Difluorobenzamide is a specialized fluorinated aromatic amide building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoroethoxy-substituted benzamide structure imparts desirable biological and physicochemical properties. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for creating novel molecules with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation herbicides and fungicides with improved selectivity and environmental profiles.
• Material Science Research: Used in the development of specialty polymers and liquid crystals, where the fluorine atoms contribute to thermal stability and unique optical properties.
• Chemical Biology: Acts as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring fluorinated aromatic compounds.

Basic Information

Product Name	2-Ethoxy-3,5-Difluorobenzamide
CAS No.	1017779-74-6
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	3,5-Difluoro-2-ethoxybenzamide; Benzamide, 3,5-difluoro-2-ethoxy-; 2-Ethoxy-3,5-difluorobenzoic acid amide; 1017779-74-6; 3,5-Difluoro-2-ethoxy-benzoic acid amide
EINECS	Contact for details

Quality Control

Our 2-Ethoxy-3,5-Difluorobenzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.