Description

4-Ethoxy-2,3-difluorophenylacetonitrile is a specialized fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the ethoxy and difluoro substitution pattern imparts specific electronic and steric properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce complex fluorinated aromatic motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in areas requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms can improve pesticidal activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the development of fluorinated liquid crystals for display technologies, leveraging its specific aromatic substitution pattern.
• Organic Electronic Materials: Employed in the synthesis of conjugated molecules and polymers for applications in OLEDs and organic photovoltaics.
• Chemical Research & Development: A versatile reagent for exploring new fluorination chemistry and constructing complex molecular architectures in academic and industrial labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on various scales.

Basic Information

Product Name	4-Ethoxy-2,3-difluorophenylacetonitrile
CAS No.	1017779-59-7
Molecular Formula	C10H9F2NO
Molecular Weight	197.18 g/mol
Synonyms	2-(4-Ethoxy-2,3-difluorophenyl)acetonitrile; (4-Ethoxy-2,3-difluorophenyl)acetonitrile; 4-Ethoxy-2,3-difluorobenzeneacetonitrile; 2,3-Difluoro-4-ethoxyphenylacetonitrile; 4-Ethoxy-2,3-difluorobenzyl cyanide; Acetonitrile, (4-ethoxy-2,3-difluorophenyl)-; 1017779-59-7
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-2,3-difluorophenylacetonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ISO standards where required for advanced intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.