Description

2-(Bromomethyl)-5-Ethoxy-1,3-Difluorobenzene is a high-purity, multi-functional aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a reactive bromomethyl group and electron-donating/withdrawing substituents, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection agent development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoro and ethoxy motifs can enhance biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals or polymers with specific electronic properties.
• Cross-Coupling Reactions: The bromomethyl group acts as an excellent electrophile for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi).
• Functional Group Transformation: Used as a starting point for further chemical modifications to introduce other functional groups via nucleophilic substitution or metal-halogen exchange.

Basic Information

Product Name	2-(Bromomethyl)-5-Ethoxy-1,3-Difluorobenzene
CAS No.	1017779-51-9
Molecular Formula	C9H9BrF2O
Molecular Weight	251.07 g/mol
Synonyms	5-Ethoxy-1,3-difluoro-2-(bromomethyl)benzene; 1-Bromomethyl-3-ethoxy-4,6-difluorobenzene; 2-(Bromomethyl)-5-ethoxy-1,3-difluorobenzene; 3-Ethoxy-4,6-difluorobenzyl bromide; Benzene, 2-(bromomethyl)-5-ethoxy-1,3-difluoro-; (3-Ethoxy-4,6-difluorophenyl)methyl bromide
EINECS	Contact for details

Quality Control

Our 2-(Bromomethyl)-5-Ethoxy-1,3-Difluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.