Description

2-(Difluoromethoxy)-4-Fluorobenzyl Bromide is a high-purity, multi-functional benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both difluoromethoxy and fluorine substituents, makes it a valuable precursor for introducing specific fluorinated motifs into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced properties. Our supply ensures consistent quality and reliable availability for your most demanding R&D and production needs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates for metabolic, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorinated benzyl group can improve biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling or modifying biomolecules in probe development and bioconjugation strategies.
• Custom Synthesis & Contract Manufacturing: A versatile starting material for custom synthesis projects and scale-up processes requiring precise fluorination.

Basic Information

Product Name	2-(Difluoromethoxy)-4-Fluorobenzyl Bromide
CAS No.	1017779-42-8
Molecular Formula	C8H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	4-Fluoro-2-(difluoromethoxy)benzyl Bromide; 1-(Bromomethyl)-4-fluoro-2-(difluoromethoxy)benzene; α-Bromo-4-fluoro-2-(difluoromethoxy)toluene; (4-Fluoro-2-(difluoromethoxy)phenyl)methyl Bromide; 2-(Difluoromethoxy)-4-fluorobenzylbromide; 1017779-42-8; Benzene, 1-(bromomethyl)-4-fluoro-2-(difluoromethoxy)-
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethoxy)-4-Fluorobenzyl Bromide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity, and impurity profiles. Our quality commitment supports compliance in cGMP and ISO-guided environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.