Description

3-Ethoxy-2,4-Difluorophenylaceticacid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluorophenylacetic acid core provides desirable metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting inflammation, CNS disorders, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Advanced Polymer Modification: Employed to introduce fluorinated aromatic side chains into polymers, altering their thermal stability, chemical resistance, and surface properties.
• Chemical Research & Development: A valuable reagent for academic and industrial research exploring new fluorination methodologies and structure-activity relationships.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-scale API batches under cGMP conditions.

Basic Information

Product Name	3-Ethoxy-2,4-Difluorophenylaceticacid
CAS No.	1017778-29-8
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	2-(3-Ethoxy-2,4-difluorophenyl)acetic acid; 3-Ethoxy-2,4-difluorobenzeneacetic acid; 1017778-29-8; 2,4-Difluoro-3-ethoxyphenylacetic acid; α-(3-Ethoxy-2,4-difluorophenyl)acetic acid; (3-Ethoxy-2,4-difluorophenyl)acetic acid; Acetic acid, 2-(3-ethoxy-2,4-difluorophenyl)-
EINECS	Contact for details

Quality Control

Our 3-Ethoxy-2,4-Difluorophenylaceticacid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure compliance with exacting industry standards. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.