Description

3-[4-(Difluoromethoxy)Phenyl]-3-Oxopropanenitrile is a high-value, specialized organic intermediate featuring a difluoromethoxy phenyl ketone moiety. This compound is critical for the synthesis of advanced molecules where the introduction of fluorine atoms and a nitrile group can significantly modulate biological activity and physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for specialty polymers and advanced organic electronic materials due to its unique electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-[4-(Difluoromethoxy)Phenyl]-3-Oxopropanenitrile
CAS No.	1017036-63-3
Molecular Formula	C10H7F2NO2
Molecular Weight	211.16 g/mol
Synonyms	4-(Difluoromethoxy)benzoylacetonitrile; 3-Oxo-3-[4-(difluoromethoxy)phenyl]propanenitrile; 1-[4-(Difluoromethoxy)phenyl]-3-oxopropanenitrile; 4-(Difluoromethoxy)phenacyl cyanide; DFMP-acetonitrile; (4-(Difluoromethoxy)benzoyl)acetonitrile; Propanenitrile, 3-[4-(difluoromethoxy)phenyl]-3-oxo-
EINECS	Contact for details

Quality Control

Our 3-[4-(Difluoromethoxy)Phenyl]-3-Oxopropanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.