Description

N~1~-(2,5-Difluorophenyl)Glycinamide Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific difluorophenyl substitution. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and process development. The material is supplied with a focus on batch-to-batch consistency and reliable supply chain logistics to support critical R&D and scale-up activities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Protease Inhibitor Research: Used in the development of enzyme inhibitors where the glycinamide moiety and fluorinated aromatic ring are critical for binding affinity and selectivity.
• Peptidomimetic Chemistry: Serves as a constrained amino acid derivative for constructing peptide analogs with enhanced metabolic stability and bioavailability.
• Agrochemical Research: Employed in the discovery of new herbicides and pesticides, leveraging the biological activity of fluorinated aromatic compounds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	N~1~-(2,5-Difluorophenyl)Glycinamide Hydrochloride
CAS No.	1016800-19-3
Molecular Formula	C8H9F2N2O·HCl
Molecular Weight	236.63 g/mol (Free base: 199.17)
Synonyms	2-Amino-N-(2,5-difluorophenyl)acetamide hydrochloride; Glycinamide, N-(2,5-difluorophenyl)-, hydrochloride; (2,5-Difluorophenyl)glycinamide HCl; N-(2,5-Difluorophenyl)glycinamide hydrochloride; 1016800-19-3; 2,5-DFP-Glycinamide HCl
EINECS	Contact for details

Quality Control

Every batch of N~1~-(2,5-Difluorophenyl)Glycinamide Hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.