Description

4-Bromo-2,3,5,6-Tetrafluorophenylboronic Acid is a highly functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its unique combination of halogen and fluorine substituents, which enable precise structural modifications and enhance the electronic properties of target molecules. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex, fluorinated bioactive molecules and active pharmaceutical ingredients (APIs) via cross-coupling.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorinated phenyl ring confers improved stability and bioavailability.
• Materials Science: Serves as a monomer or precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Essential for medicinal chemistry programs and structure-activity relationship (SAR) studies to explore new chemical entities.
• Suzuki-Miyaura Cross-Coupling: Acts as a versatile boron-containing coupling partner with aryl/vinyl halides to form biaryl and other C-C bonds under palladium catalysis.
• Fluorine Chemistry: A valuable reagent for introducing perfluorinated aromatic segments into target compounds, leveraging the properties of fluorine atoms.

Basic Information

Product Name	4-Bromo-2,3,5,6-Tetrafluorophenylboronic Acid
CAS No.	1016231-40-5
Molecular Formula	C6H2BBrF4O2
Molecular Weight	272.79 g/mol
Synonyms	(4-Bromo-2,3,5,6-tetrafluorophenyl)boronic acid; B-(4-Bromo-2,3,5,6-tetrafluorophenyl)boronic acid; 4-Bromo-2,3,5,6-tetrafluorobenzeneboronic acid; 2,3,5,6-Tetrafluoro-4-bromophenylboronic acid; 1016231-40-5; Boronic acid, B-(4-bromo-2,3,5,6-tetrafluorophenyl)-; AKOS040759415
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3,5,6-Tetrafluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.