Description

2-[2-Methyl-D3-3-(Trifluoromethyl)Phenylamino]Nicotinic Acid is a deuterated and fluorinated nicotinic acid derivative, a high-value synthetic intermediate designed for advanced research and development. This compound is critical for applications requiring isotopic labeling and enhanced metabolic stability, offering significant advantages in pharmacokinetic and mechanistic studies. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and deuterated drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of deuterated drug molecules, leveraging the kinetic isotope effect for improved metabolic profiles.
• Metabolic Tracer Development: Used in the creation of labeled compounds for mass spectrometry-based studies in drug metabolism and pharmacokinetics (DMPK).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in lead optimization programs.
• Reference Standard Production: Manufactured to high purity for use as an analytical standard in quality control laboratories.
• Biochemical Probe Synthesis: Incorporated into molecules designed to investigate specific biological pathways and enzyme functions.
• Contract Research & Development (CRO): Supplied to CROs and academic institutions for custom synthesis and exploratory research projects.

Basic Information

Product Name	2-[2-Methyl-D3-3-(Trifluoromethyl)Phenylamino]Nicotinic Acid
CAS No.	1015856-60-6
Molecular Formula	C14H9D3F3N2O2
Molecular Weight	300.27 g/mol
Synonyms	2-[(2-Methyl-d3-3-(trifluoromethyl)phenyl)amino]nicotinic acid; 2-((2-(Methyl-d3)-3-(trifluoromethyl)phenyl)amino)pyridine-3-carboxylic acid; Nicotinic acid, 2-[(2-methyl-d3-3-(trifluoromethyl)phenyl)amino]-; 2-[(2-(Methyl-d3)-3-(trifluoromethyl)anilino)]nicotinic acid; Deuteronated Niflumic Acid Derivative; Deuterated Trifluoromethyl Anilino Nicotinate
EINECS	Contact for details

Quality Control

Every batch of 2-[2-Methyl-D3-3-(Trifluoromethyl)Phenylamino]Nicotinic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA), including results from NMR (¹H, ¹³C, ¹⁹F), HPLC, and mass spectrometry, is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.