Description

Bicifadine-D5 Hydrochloride is a deuterated analog of the serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) Bicifadine, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is essential for high-precision analytical research, providing an internal standard for accurate quantification and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetics, bioanalytical method development, and drug metabolism research.

Application

• Internal standard for the quantitative analysis of Bicifadine and its metabolites via LC-MS/MS and GC-MS.
• Use in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug absorption, distribution, metabolism, and excretion.
• Metabolite identification and profiling in drug discovery and development pipelines.
• Bioanalytical method validation to ensure accuracy, precision, and regulatory compliance.
• Research into the mechanisms of triple monoamine reuptake inhibition and related neurological pathways.
• Stable isotope dilution analysis for ensuring data integrity in complex biological matrices.

Basic Information

Product Name	Bicifadine-D5 Hydrochloride
CAS No.	1014696-75-3
Molecular Formula	C12H12D5NO • HCl
Molecular Weight	Contact for details
Synonyms	(±)-1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexane-D5 Hydrochloride; Bicifadine-d5 HCl; DW-8394-d5; 1-(p-Tolyl)-3-azabicyclo[3.1.0]hexane-D5 Hydrochloride; Dexoxadrol Analog-d5 Hydrochloride; SNDRI Internal Standard-d5
EINECS	Contact for details

Quality Control

Our Bicifadine-D5 Hydrochloride is manufactured under controlled conditions to ensure the highest isotopic and chemical purity, critical for its role as an analytical standard. Each batch undergoes rigorous testing, including NMR and mass spectrometry for isotopic enrichment verification and HPLC for chemical purity assessment. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, and isotopic abundance are provided to support your GLP and regulatory compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Assay (HPLC)	≥ 98.0%
Chemical Purity (HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.