Description

(R)-Fmoc-4-Amino-5-tert-Butoxy-Pentanoic Acid CAS NO 1014018-79-1 is a high-purity, non-natural amino acid derivative featuring an orthogonal Fmoc protecting group and a tert-butoxy side chain. This compound is a critical chiral building block designed for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, constrained analogs, and bioactive molecules where precise stereochemistry and side-chain functionality are required.

Application

• Peptide Synthesis: A key chiral intermediate for the Fmoc-based solid-phase peptide synthesis (SPPS) of complex peptide sequences.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based drugs, including hormone analogs, enzyme inhibitors, and receptor ligands.
• Peptidomimetic Design: Incorporation into peptidomimetic scaffolds to enhance metabolic stability, bioavailability, and target binding affinity.
• Bioconjugation: Serves as a specialized linker or functional handle for the site-specific modification of peptides and proteins.
• Chemical Biology Probes: Synthesis of labeled or tagged peptides used as tools for studying protein-protein interactions and cellular pathways.
• Academic Research: Fundamental studies in organic synthesis, asymmetric synthesis, and peptide chemistry within university and institutional laboratories.

Basic Information

Item	Detail
Product Name	(R)-Fmoc-4-Amino-5-tert-Butoxy-Pentanoic Acid
CAS No.	1014018-79-1
Molecular Formula	C24H29NO5
Molecular Weight	411.49 g/mol
Synonyms	(R)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-amino-5-(tert-butoxy)pentanoic acid; Fmoc-D-4-Amino-5-tert-butoxypentanoic acid; Fmoc-(R)-4-Amino-5-(tert-butoxy)valeric acid; (R)-5-(tert-Butoxy)-4-[(9H-fluoren-9-ylmethoxy)carbonylamino]pentanoic acid; Fmoc-D-Abu(OBut)-OH; Fmoc-D-γ-Amino-δ-tert-butoxyvaleric Acid
EINECS	Contact for details

Quality Control

Our (R)-Fmoc-4-Amino-5-tert-Butoxy-Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications are tailored to meet the stringent demands of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.