Description

1-(Chloroacetyl)-4-(tert-Butoxycarbonyl)-Aminopiperidine is a high-purity, advanced pharmaceutical intermediate used in the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for medicinal chemistry research and development, particularly in constructing piperidine-based scaffolds with protected amine functionality. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of novel therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of piperidine-containing drug candidates, including potential kinase inhibitors and central nervous system (CNS) agents.
• Medicinal Chemistry Research: Used in parallel synthesis and combinatorial chemistry for creating focused libraries to explore structure-activity relationships (SAR).
• Peptidomimetic Synthesis: Serves as a crucial component in the development of peptidomimetics and protease inhibitors due to its protected amine and reactive chloroacetyl group.
• API Development: Employed in the pilot-scale and commercial-scale production routes for advanced pharmaceutical ingredients requiring a Boc-protected aminopiperidine moiety.
• Custom Synthesis: Foundation for contract manufacturing and custom synthesis projects targeting specific molecular architectures for client-specific applications.

Basic Information

Product Name	1-(Chloroacetyl)-4-(tert-Butoxycarbonyl)-Aminopiperidine
CAS No.	1013921-00-0
Molecular Formula	C12H21ClN2O3
Molecular Weight	276.76 g/mol
Synonyms	1-(Chloroacetyl)-4-[(tert-butoxy)carbonyl]aminopiperidine; 4-[(tert-Butoxycarbonyl)amino]-1-(chloroacetyl)piperidine; 1-(Chloroacetyl)-4-(Boc-amino)piperidine; tert-Butyl N-[1-(2-chloroacetyl)piperidin-4-yl]carbamate; 4-(Boc-amino)-1-chloroacetylpiperidine; 1-Chloroacetyl-4-(N-Boc-amino)piperidine; Piperidine, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-(chloroacetyl)-
EINECS	Contact for details

Quality Control

Our 1-(Chloroacetyl)-4-(tert-Butoxycarbonyl)-Aminopiperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP-compliant development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be stored away from light. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.