Description

1-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-Methylcyclohexane-1-Carboxylic Acid is a specialized Fmoc-protected amino acid derivative, a critical building block in modern peptide synthesis. This compound is engineered to provide high coupling efficiency and stereochemical integrity during solid-phase and solution-phase peptide assembly. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of novel therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the controlled, sequential assembly of custom peptide sequences.
• Solution-Phase Peptide Synthesis: Used in the synthesis of shorter peptide chains or where solution-phase methodologies are preferred.
• Pharmaceutical Intermediate: Serves as a crucial intermediate in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Incorporates the 4-methylcyclohexane backbone to create peptides with enhanced metabolic stability and conformational rigidity.
• Bioconjugation and Labeling: The carboxylic acid group allows for further functionalization and conjugation to other molecules or surfaces.
• Combinatorial Chemistry Libraries: Used to generate diverse libraries of compounds for high-throughput screening in drug discovery.
• Academic and Industrial Research: A fundamental reagent for studying protein-protein interactions and structure-activity relationships (SAR).

Basic Information

Product Name	1-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-Methylcyclohexane-1-Carboxylic Acid
CAS No.	1013096-03-1
Molecular Formula	C24H27NO4
Molecular Weight	393.48 g/mol
Synonyms	Fmoc-4-methylcyclohexylglycine; Fmoc-MeChg-OH; 1-[(9-Fluorenylmethoxycarbonyl)amino]-4-methylcyclohexane-1-carboxylic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methyl-L-cyclohexylglycine; Fmoc-4-Me-Chg-OH; (1R,4R)- and (1S,4S)-Fmoc-4-methylcyclohexylglycine (isomeric mixture); 4-Methyl-Fmoc-cyclohexylglycine; Fmoc-protected 4-methylcyclohexylglycine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for peptide synthesis reagents. Each batch is analyzed to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request, detailing results from HPLC, NMR, and other relevant analytical methods. We adhere to a strict quality management system to guarantee batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant after opening to prevent degradation. For long-term storage, consider storage at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.