Description

Chloramphenicol 1-o-β-D-Glucuronide is a crucial reference standard and metabolite used primarily in pharmaceutical research and analytical chemistry. This compound is essential for the accurate quantification and metabolic profiling of the antibiotic chloramphenicol, ensuring reliable data in pharmacokinetic and toxicological studies. It is a vital reagent for laboratories in the pharmaceutical, contract research organization (CRO), and regulatory testing sectors that require high-purity analytical standards for method development and validation.

Application

• Pharmaceutical Reference Standard: Used as a certified primary standard for the calibration of analytical instruments in drug development and quality control.
• Metabolite Analysis: Critical for studying the metabolic pathways, pharmacokinetics, and bioavailability of Chloramphenicol in biological matrices.
• Bioanalytical Method Development: Serves as a key component in developing and validating HPLC, LC-MS, and other chromatographic assays for drug and metabolite detection.
• Toxicology and Doping Control: Employed in forensic and sports anti-doping laboratories to accurately identify and quantify Chloramphenicol and its metabolites.
• Veterinary Drug Residue Testing: Used in food safety programs to monitor for Chloramphenicol residues in animal-derived products, ensuring regulatory compliance.
• Academic and Clinical Research: Supports fundamental research into antibiotic metabolism, resistance mechanisms, and clinical efficacy studies.

Basic Information

Product Name	Chloramphenicol 1-o-β-D-Glucuronide
CAS No.	1013074-93-5
Molecular Formula	C21H25Cl2NO11
Molecular Weight	538.33 g/mol
Synonyms	Chloramphenicol 1-O-β-D-Glucuronide; Chloramphenicol Glucuronide; Chloramphenicol β-D-Glucuronide; 1-O-(β-D-Glucopyranosyluronic acid) Chloramphenicol; Chloramphenicol 1-O-β-D-Glucopyranosiduronic Acid; (2R,3R)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our Chloramphenicol 1-o-β-D-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for analytical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically verified by HPLC, NMR, and mass spectrometry. We adhere to relevant industry standards for reference materials to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.