Description

(2R,4R)-5-(Biphenyl-4-Yl)-4-[(tert-Butoxycarbonyl)Amino]-2-Methylpentanoic Acid is a high-purity, non-natural amino acid derivative featuring a chiral backbone and a biphenyl side chain. This compound is a critical chiral building block and intermediate in modern pharmaceutical synthesis, valued for its role in constructing complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel peptide drugs and protease inhibitors.
• Chemical Biology Research: Used in the synthesis of custom amino acids for studying protein structure, function, and protein-protein interactions.
• Medicinal Chemistry: Serves as a building block for constructing focused libraries in drug discovery programs targeting various diseases.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective synthesis due to its defined (2R,4R) configuration.
• API Development: Integral in the synthetic route for advanced pharmaceutical candidates requiring specific chiral centers and lipophilic character.

Basic Information

Product Name	(2R,4R)-5-(Biphenyl-4-Yl)-4-[(tert-Butoxycarbonyl)Amino]-2-Methylpentanoic Acid
CAS No.	1012341-56-8
Molecular Formula	C23H29NO4
Molecular Weight	383.48 g/mol
Synonyms	Boc-D-Biphenylalanine; (2R,4R)-4-[(tert-Butoxycarbonyl)amino]-2-methyl-5-(4-phenylphenyl)pentanoic acid; (2R,4R)-Boc-Amino-2-methyl-5-(biphenyl-4-yl)pentanoic Acid; Boc-D-4-BiphenylAla-OH; N-Boc-4-biphenyl-D-homoalanine; N-tert-Butoxycarbonyl-4-biphenyl-D-homoalanine; (R,R)-Boc-Biphenylalanine
EINECS	Contact for details

Quality Control

Our (2R,4R)-5-(Biphenyl-4-Yl)-4-[(tert-Butoxycarbonyl)Amino]-2-Methylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.