Description

Carbamic Acid, n-[(1R)-3-(Methylamino)-3-Oxo-1-[(Phenylthio)Methyl]Propyl]-, Phenylmethyl Ester is a sophisticated chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting complex biological pathways. Pharmaceutical R&D teams and fine chemical manufacturers need this high-purity intermediate to ensure the stereochemical integrity and efficacy of their final drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of proprietary drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetic Research: Serves as a constrained scaffold in the design and synthesis of peptidomimetics and protease inhibitors.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric transformations to introduce complex molecular architectures.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs for novel molecular entities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and niche APIs.
• Chemical Biology Probes: Used in the development of chemical probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	Carbamic Acid, n-[(1R)-3-(Methylamino)-3-Oxo-1-[(Phenylthio)Methyl]Propyl]-, Phenylmethyl Ester
CAS No.	1012059-96-9
Molecular Formula	C19H22N2O3S
Molecular Weight	358.45 g/mol
Synonyms	Benzyl (2R)-2-[(benzyloxycarbonyl)amino]-4-(methylamino)-4-oxobutyl phenyl sulfide; (R)-Benzyl 2-((((benzyloxy)carbonyl)amino)-4-(methylamino)-4-oxobutyl)phenyl sulfane; N-Cbz-3-(Methylamino)-3-oxo-1-[(phenylthio)methyl]-1-propylamine, Benzyl Ester; (R)-N-[(Benzyloxy)carbonyl]-N-methyl-β-alanine Phenylmethyl Ester Thioether Derivative; CAS 1012059-96-9; Z-Protected β-Amino Acid Thioether Derivative; Chiral Carbamate Sulfide Intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing applications. Quality is verified through comprehensive analytical methods including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.