Description

Benzene, 2-Bromo-4-(Bromomethyl)-1-(Trifluoromethoxy)- is a specialized halogenated benzene derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its unique molecular structure, which incorporates bromine and trifluoromethoxy functional groups, enabling precise chemical modifications and the introduction of specific properties into target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring halogenated aromatic cores for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, where the bromine atoms and trifluoromethoxy group can contribute to potency and environmental persistence.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, or organic electronic materials that benefit from its specific halogen and fluorine content.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck, Stille) due to the reactive bromine substituents, enabling carbon-carbon bond formation.
• Fluorine Chemistry: The trifluoromethoxy group makes it a valuable reagent for studying and incorporating fluorinated motifs, which are highly sought-after in medicinal and materials chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies and CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Benzene, 2-Bromo-4-(Bromomethyl)-1-(Trifluoromethoxy)-
CAS No.	1011531-45-5
Molecular Formula	C8H5Br2F3O
Molecular Weight	333.93 g/mol
Synonyms	1-(Trifluoromethoxy)-2-bromo-4-(bromomethyl)benzene; 2-Bromo-4-(bromomethyl)-1-(trifluoromethoxy)benzene; 4-Bromomethyl-2-bromo-1-(trifluoromethoxy)benzene; 2-Bromo-1-(trifluoromethoxy)-4-(bromomethyl)benzene; [2-Bromo-4-(bromomethyl)phenyl] trifluoromethyl ether; Benzene, 1-(trifluoromethoxy)-2-bromo-4-(bromomethyl)- (9CI)
EINECS	Contact for details

Quality Control

Our Benzene, 2-Bromo-4-(Bromomethyl)-1-(Trifluoromethoxy)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.