Description

R-3,3'-Bis((3,5-Bis(Trifluoromethyl)Phenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate is a sophisticated chiral organophosphorus compound, specifically designed as a high-performance ligand for asymmetric catalysis. Its value lies in its unique sterically hindered, electron-deficient structure, which provides exceptional enantioselectivity and catalytic activity in critical synthetic transformations. This advanced chemical is essential for R&D and production chemists in the pharmaceutical and fine chemical industries, where it enables the synthesis of complex, single-enantiomer intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand for transition-metal-catalyzed reactions, including hydrogenation, C-C bond formation, and conjugate additions.
• Pharmaceutical Synthesis: Critical for the enantioselective production of chiral drug candidates and complex API intermediates, improving yield and purity.
• Fine Chemical Manufacturing: Used in the synthesis of high-value specialty chemicals, agrochemicals, and flavors & fragrances requiring precise stereochemical control.
• Academic & Industrial R&D: A key tool for developing novel catalytic methodologies and exploring new reaction pathways in process chemistry.
• Ligand Screening Libraries: An important component in catalyst discovery and optimization kits for high-throughput screening.
• Material Science Research: Potential applications in the development of chiral polymers or advanced materials with specific optical properties.

Basic Information

Product Name	R-3,3'-Bis((3,5-Bis(Trifluoromethyl)Phenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate
CAS No.	1011465-24-9
Molecular Formula	C52H34F12O4P2
Molecular Weight	1012.78 g/mol
Synonyms	(R)-3,3'-Bis[3,5-bis(trifluoromethyl)phenyl]-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; (R)-H8-BINAP-3,3'-diyl-bis(3,5-bis(trifluoromethyl)phenyl)phosphate; R-H8-BINAP-3,3'-bis(3,5-bis(trifluoromethyl)phenyl)phosphate; R-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-H8-BINOL phosphate; Chiral BINAP-derived phosphate ligand; Octahydro-BINAP-based phosphoric acid ligand; (R)-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-[1,1'-binaphthalene]-2,2'-diyl hydrogenphosphate
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Every lot is characterized using advanced analytical techniques, including Chiral HPLC to confirm enantiomeric excess (ee) and NMR spectroscopy for structural verification. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific analytical data is provided with each shipment. We support development and scale-up needs with custom purity grades and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment, and consideration should be given to handling under an inert atmosphere for long-term storage to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.