Description

(R)-3,3'-Bis(2,4,6-Trimethylphenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2-Naphthyl Hydrogen Phosphate is a high-purity, chiral organophosphorus compound that serves as a highly effective and selective catalyst or ligand in asymmetric synthesis. Its value lies in enabling the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs) with superior optical purity. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance chiral auxiliaries.

Application

• Asymmetric Catalysis: As a chiral Brønsted acid catalyst for enantioselective transformations such as Mannich reactions, Pictet–Spengler reactions, and transfer hydrogenations.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral drug candidates and APIs, particularly in the synthesis of complex molecules requiring high enantiomeric excess (ee).
• Ligand for Metal Complexes: Can be used to form chiral metal-ligand complexes for asymmetric C–C bond formation reactions, including cross-couplings and cycloadditions.
• Agrochemical Research: Employed in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: Potential application in the synthesis of chiral polymers or as a dopant for liquid crystal displays (LCDs).
• Academic & Industrial R&D: A valuable tool for method development and exploring new asymmetric synthetic pathways in laboratory settings.

Basic Information

Product Name	(R)-3,3'-Bis(2,4,6-Trimethylphenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2-Naphthyl Hydrogen Phosphate
CAS No.	1011465-23-8
Molecular Formula	C44H47O4P
Molecular Weight	670.81 g/mol
Synonyms	(R)-H8-BINOL Phosphoric Acid Derivative; (R)-3,3'-Bis(mesityl)-H8-BINOL Phosphate; (R)-Octahydro-BINOL-Derived Phosphoric Acid; (R)-H8-BINAP Acid Phosphate; (R)-2,2'-Dihydroxy-1,1'-binaphthyl-3,3'-diylbis(2,4,6-trimethylphenyl) Hydrogen Phosphate (partially hydrogenated derivative); (R)-TRIP Analog (H8); Chiral Brønsted Acid Catalyst (R)-form; Contact for additional names.
EINECS	Contact for details

Quality Control

Our (R)-3,3'-Bis(2,4,6-Trimethylphenyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2-Naphthyl Hydrogen Phosphate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and ICP-MS for trace metal analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring compliance with your research and process development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.