Description

2-Iodo-n-(Prop-2-Yn-1-Yl)Acetamide is a specialized organic building block featuring a reactive iodoacetyl group and a terminal alkyne moiety, making it a valuable intermediate for click chemistry and bioconjugation applications. Its molecular design enables efficient, site-specific modifications of biomolecules and polymers under mild conditions. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of targeted drug candidates, particularly for antibody-drug conjugates (ADCs) and other biopharmaceuticals.
• Bioconjugation Reagent: Used for the selective labeling and modification of peptides, proteins, and antibodies via reactions with thiol or amine groups.
• Click Chemistry Substrate: The terminal alkyne group participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for modular synthesis.
• Polymer Functionalization: Employed to introduce iodoacetamide functionalities into polymer backbones for creating advanced materials with specific reactivity.
• Agrochemical Research: Acts as a building block for developing novel crop protection agents and herbicides.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzyme function and protein interactions.

Basic Information

Product Name	2-Iodo-n-(Prop-2-Yn-1-Yl)Acetamide
CAS No.	1010386-64-7
Molecular Formula	C5H6INO
Molecular Weight	222.01 g/mol
Synonyms	N-(Prop-2-yn-1-yl)-2-iodoacetamide; 2-Iodo-N-(2-propynyl)acetamide; Iodoacetamide propargyl; Propargyl iodoacetamide; N-Propargyl-2-iodoacetamide; 2-Iodoacetamide propargyl ester; Iodoacetic acid propargylamide; CAS 1010386-64-7
EINECS	Contact for details

Quality Control

Our 2-Iodo-n-(Prop-2-Yn-1-Yl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every lot upon request, supporting your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be performed under subdued lighting where practical.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.