Description

3,3-Difluoropropan-1-Amine Hydrochloride is a high-purity, organofluorine building block essential for advanced chemical synthesis. This compound is valued for its role in introducing the difluoromethylene ether bioisostere and other fluorine-containing motifs into target molecules, which can dramatically alter their physicochemical and pharmacokinetic properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting metabolic diseases, CNS disorders, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Fluorinated Material Precursor: Serves as a starting material for the development of specialty fluorinated polymers, surfactants, and liquid crystals with unique performance characteristics.
• Bioconjugation & Probe Development: Employed in chemical biology for labeling and modifying biomolecules to create diagnostic tools and research probes.
• Peptidomimetics & Drug Design: Integral for constructing fluorinated amino acid analogs and peptidomimetics to improve metabolic stability and membrane permeability of peptide-based therapeutics.

Basic Information

Product Name	3,3-Difluoropropan-1-Amine Hydrochloride
CAS No.	1010097-89-8
Molecular Formula	C3H8ClF2N
Molecular Weight	131.55 g/mol
Synonyms	3,3-Difluoropropylamine Hydrochloride; 3,3-Difluoro-1-propanamine Hydrochloride; 1-Amino-3,3-difluoropropane Hydrochloride; 3,3-Difluoropropanamine HCl; 3,3-Difluoropropylammonium Chloride; (3,3-Difluoropropyl)amine Hydrochloride; 3,3-Difluoro-1-propanaminium chloride
EINECS	Contact for details

Quality Control

Our 3,3-Difluoropropan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistent performance. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.