Description

(E)-Methyl 3-(2,5-Difluorophenyl)Acrylate is a high-purity fluorinated acrylate ester building block, essential for advanced organic synthesis. Its core value lies in the strategic incorporation of fluorine atoms and the reactive acrylate moiety, enabling precise molecular design for enhanced performance characteristics. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel drug candidates, particularly for kinase inhibitors and CNS-active compounds where fluorine substitution modulates bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in constructing advanced active ingredients for crop protection, leveraging the difluorophenyl group for improved lipophilicity and target binding.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored surface properties, chemical resistance, and optical characteristics.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic display and lighting applications, where the acrylate group facilitates polymerization and the fluorine atoms influence electronic properties.
• Chemical Biology Probe Development: Acts as a versatile handle for introducing photoaffinity labels, fluorophores, or other reporter groups via Michael addition or other conjugate reactions.
• Cross-Coupling Reactions: The acrylate double bond and aromatic ring make it a suitable substrate for various palladium-catalyzed coupling reactions to build complex molecular architectures.

Basic Information

Product Name	(E)-Methyl 3-(2,5-Difluorophenyl)Acrylate
CAS No.	1007862-01-2
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	Methyl (2E)-3-(2,5-Difluorophenyl)-2-propenoate; (E)-Methyl 3-(2,5-Difluorophenyl)propenoate; trans-Methyl 3-(2,5-Difluorocinnamate); 2-Propenoic acid, 3-(2,5-difluorophenyl)-, methyl ester, (2E)-; Methyl (E)-3-(2,5-difluorophenyl)acrylate; 2,5-Difluorocinnamic acid methyl ester
EINECS	Contact for details

Quality Control

Our (E)-Methyl 3-(2,5-Difluorophenyl)Acrylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Isomeric Purity ((E)-isomer)	≥ 99.0% (by HPLC or NMR)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.