Description

Codeine-D6 is a deuterium-labeled internal standard of the opioid analgesic codeine, essential for precise quantitative analysis in complex matrices. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based methods, eliminating variability and improving data integrity. It is primarily required by pharmaceutical research laboratories, forensic toxicology units, and clinical diagnostic facilities for applications such as pharmacokinetic studies, drug metabolism research, and compliance testing.

Application

• Internal Standard for LC-MS/MS and GC-MS: Used as a quantitative reference in bioanalytical method development and validation for the accurate measurement of codeine and its metabolites in biological samples (plasma, urine, serum).
• Pharmacokinetic and Drug Metabolism Studies: Enables precise tracking of absorption, distribution, metabolism, and excretion (ADME) profiles of codeine in preclinical and clinical research.
• Forensic and Clinical Toxicology: Supports reliable quantification in workplace drug testing, post-mortem analysis, and cases of suspected overdose or substance abuse.
• Pharmaceutical Quality Control: Assists in the impurity profiling and assay of codeine in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the labeled spike in this high-precision technique for definitive method development and reference material characterization.

Basic Information

Product Name	Codeine-D6
CAS No.	1007844-34-9
Molecular Formula	C₁₈H₁₅D₆NO₃
Molecular Weight	305.39 g/mol
Synonyms	Codeine-d6; (5α,6α)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol-d6; Morphine-3-methyl ether-d6; 3-Methylmorphine-d6; Codicept-d6; Methylmorphine-d6; Paveral-d6
EINECS	Contact for details

Quality Control

Our Codeine-D6 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), and confirmation of structure. We adhere to relevant industry guidelines for reference standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.